《一女一男》是一个现代故事，讲述的是年轻人在当今社会复杂的人际关系、联系和亲密关系中穿梭的故事。这部电影讲述了一个女孩的故事，一个男孩的故事，以及一个女孩和一个男孩的故事。

　　In a dark, velvety theatre there is a first kiss between Pietro and Tommaso. When the lights come back on, however, the two students have different expectations of what might follow.

　　Driving home late at night during a heavy rainstorm, Glen experiences car trouble. Near where his car gets stuck, he spots a house, knocks on the door and is greeted by an oddly friendly middle-aged man, Arthur, and his younger wife, Cyn…

某天，心理学学生艾比·琼斯（Christine Evangelista 饰）随同学还有教授一同前往帕克精神病院观摩。早在3年前，艾比罹患精神病的父亲便在这所医院自杀。可是为了帮更多患者走出阴影，这个勤奋勇敢的女孩还是踏入了这幢充满恐慌的建筑。在此期间，艾比意外遭到橙色高危精神病患者哈蒙（Dominic Purcell 饰）的袭击，备受惊吓。观摩结束之后，艾…